Competing Physiology
Renal perfusion, hydration, congestion risk, blood pressure, and cardiac output can pull treatment in different directions.
Cardiorenal Care Initiative • Miami
The Happy Project is developing practical tools to improve medication reconciliation, monitoring, handoffs, and owner communication for pets living with both cardiac and kidney disease.
Starting with one high-risk clinical problem. Building the system before building the hospital.
Hydration, renal perfusion, respiratory status, blood pressure, and chronic heart medications all interact. The goal is to make those decisions explicit and visible.
Our Mission
We are focused initially on dogs and cats living with both heart disease and chronic kidney disease, especially during acute illness, hospitalization, medication changes, and discharge.
The goal is not to tell veterinarians how to practice medicine. It is to create practical systems that make important clinical decisions easier to document, communicate, and carry across shifts and between hospitals, specialists, primary veterinarians, and owners.
Why Cardiorenal Care
A patient may need fluid support for the kidneys while also having heart disease that limits how aggressively fluids can be given. Chronic medications may remain essential—or may require reassessment during an acute crisis. The safest plan depends on seeing the entire clinical picture together.
Renal perfusion, hydration, congestion risk, blood pressure, and cardiac output can pull treatment in different directions.
Diuretics, ACE inhibitors, inotropes, and adjunctive cardiac drugs should be reconciled against the patient’s current status.
Clinical reasoning can disappear across referrals, overnight shifts, and discharge unless it is explicitly documented.
Cardiac Monitoring & Medications
Heart and kidney disease cannot be managed in isolation. Respiratory trends, blood pressure, hydration, renal values, and medication effects all belong in the same clinical picture. The tools below are designed to help owners monitor and ask better questions—not to change medications without veterinary direction.
Home sleeping or resting respiratory-rate monitoring can be useful in dogs with heart disease, especially those with a history of congestive heart failure. Healthy and clinically controlled dogs often have sleeping rates below 30 breaths per minute, but each patient should have an individualized baseline and action plan from the veterinary team.
Systemic hypertension can worsen kidney and other target-organ injury, while hypotension can compromise perfusion. In CKD, IRIS recommends repeated systolic blood-pressure measurement and interpretation in context, including stress or "white-coat" effects.
Ask your veterinarian: What was the systolic blood pressure? Was the reading repeated under standardized conditions? What is the patient's target, and when should it be rechecked?
Medication Guide
These summaries are educational. Whether a drug should be continued, held, reduced, restarted, or replaced depends on the individual patient and must be decided by the treating veterinarian.
Class: Loop diuretic
Role: Promotes urine production to relieve pathologic fluid accumulation, including pulmonary edema in CHF.
Cardiorenal question: Does the patient currently need diuresis, and how should the dose be balanced against hydration, renal function, electrolytes, respiratory status, and congestion?
Ask: "Given today's respiratory findings, hydration, renal values, and electrolytes, is the current furosemide plan still appropriate?"
Class: Renin-angiotensin-aldosterone system (RAAS) inhibitor
Role: Used in selected cardiac patients and in some renal patients for blood-pressure and proteinuria management.
Cardiorenal question: RAAS inhibition can affect systemic and glomerular hemodynamics, so blood pressure, renal function, hydration, and proteinuria should be considered together—especially in unstable or azotemic patients.
Ask: "What is the indication for enalapril in this patient, and what blood-pressure and renal monitoring supports the current plan?"
Class: Inodilator / positive inotrope
Role: Improves cardiac contractility and has vasodilatory effects; it is commonly used in appropriately staged canine heart disease.
Cardiorenal question: Pimobendan is not a diuretic, but whether it should be continued still depends on the patient's cardiac diagnosis, stage, blood pressure, rhythm, and overall clinical condition.
Ask: "What cardiac indication are we treating with pimobendan, and should that plan change during this acute illness?"
Class: Potassium-sparing diuretic / mineralocorticoid-receptor antagonist
Role: Used as an adjunct in selected CHF patients; its diuretic effect is milder than furosemide.
Cardiorenal question: Kidney function, hydration, potassium, concurrent RAAS drugs, and the ongoing cardiac indication should be reviewed.
Ask: "What is today's potassium and renal status, and what benefit are we expecting from spironolactone right now?"
Cardiac Diagnostics
Ultrasound of the heart. Assesses chamber size, valve structure and function, contractility, blood-flow patterns, and other structural/hemodynamic features.
Records the heart's electrical activity. Used primarily to assess rhythm and conduction; it is not the same test as an echocardiogram.
Chest X-rays help assess heart size, pulmonary vessels, lung patterns, pulmonary edema, and pleural fluid. They are interpreted together with examination and clinical signs.
Can provide evidence of myocardial stretch or cardiac stress in selected situations. They complement—not replace—physical examination and imaging.
Especially important in kidney disease, suspected hypertension, and patients receiving therapies that affect cardiovascular or renal hemodynamics.
Home SRR/RRR trends can be paired with examination and imaging to help recognize changing congestion risk earlier.
Navigating Veterinary Care
“Veterinarian,” “specialist,” “clinic,” and “hospital” are not interchangeable terms. When a dog has both heart and kidney disease, knowing the training of the clinician and the capabilities of the facility can matter as much as knowing the diagnosis.
Who Is Who?
A veterinarian who has earned a professional veterinary medical degree. DVM and VMD are equivalent veterinary degrees.
Often the right starting point for: routine examinations, preventive care, stable chronic disease, basic diagnostics, blood-pressure checks, medication refills, and coordination of referrals.
A veterinarian who completed advanced specialty training and board certification in small-animal internal medicine through the American College of Veterinary Internal Medicine.
Especially useful for: complicated CKD, severe azotemia, anemia, electrolyte disorders, GI disease, endocrine disease, proteinuria, and difficult multisystem cases.
A veterinarian with advanced residency training and board certification in veterinary cardiology.
Especially useful for: echocardiography, complex CHF, valve disease, cardiomyopathy, arrhythmias, cardiac staging, and difficult cardiac-medication decisions.
A veterinarian board certified in emergency and critical care after advanced specialty training.
Especially useful for: unstable hospitalized patients, respiratory distress, shock, severe metabolic disturbances, intensive monitoring, and complex ICU decisions.
A veterinary specialist with advanced training and board certification in nutrition.
Especially useful for: creating nutritionally complete homemade diets for patients whose kidney, cardiac, GI, pancreatic, or other medical needs make ordinary feeding plans difficult.
Where Are You?
The word “hospital” alone does not tell you which specialists, ICU capabilities, advanced procedures, or overnight medical coverage are available. Ask about capabilities directly.
Best suited to routine and stable care: examinations, vaccinations, basic imaging and laboratory testing, chronic-disease monitoring, blood-pressure checks, and medication management within the practice's capabilities.
Escalate when: the disease becomes unstable, diagnosis is unclear, advanced imaging/procedures are needed, or multiple organ systems require specialist coordination.
Designed to evaluate emergencies and often provide hospitalization, IV therapy, oxygen, repeated laboratory testing, imaging, and continuous nursing support.
Important: 24-hour emergency care does not automatically mean that an internist, cardiologist, or criticalist is physically present around the clock.
May combine emergency care with board-certified specialists such as internal medicine, cardiology, surgery, neurology, oncology, and critical care, plus advanced diagnostics and procedures.
Ask: Which specialists are physically available today? Who will manage the patient overnight? Which advanced services are actually offered at this location?
A high-level referral center—often a veterinary teaching hospital or major specialty institution—capable of coordinating multiple specialty services and, at some centers, advanced renal replacement therapy, complex ICU support, interventional procedures, and uncommon diagnostics.
Think tertiary early when: the patient has severe multisystem disease, requires technology the current hospital does not possess, or is failing to respond despite appropriate specialty-level treatment.
Find the Right Level of Care
When Your Dog Is Hospitalized
Get the attending veterinarian's name. Ask who takes over at shift change and who is responsible overnight.
Ask for current laboratory results and trends, hydration/volume assessment, respiratory findings, blood pressure when relevant, appetite, urine output, weight, and important events.
Ask which medications were continued, held, reduced, added, or restarted and the clinical reasoning for each change.
Know what the team is trying to accomplish, which parameters will be rechecked, and what findings would cause the plan to change.
Ask what deterioration would require a specialist, ICU transfer, dialysis-capable center, or another higher level of care.
Request current labs, treatment plans, medication information, imaging reports, and other available records needed to understand the case or seek another opinion.
Hospital → Home
Discharge is a high-risk transition. Before leaving, the owner and veterinary team should be looking at the same medication list, the same monitoring plan, and the same follow-up schedule.
For every drug: continue, stop, hold, change, or restart? Confirm the dose, timing, purpose, and what would trigger another change.
Review important lab trends, hydration/volume status, respiratory findings, blood pressure when relevant, appetite, urine output, and unresolved problems.
Know what to measure at home—such as sleeping respiratory rate, weight, appetite, water/food intake, urine changes, and prescribed medication observations.
Get written instructions for what requires a routine call, a same-day assessment, or emergency evaluation.
Know when CBC/chemistry, blood pressure, weight, imaging, or specialist follow-up should occur and who owns that follow-up.
Request the available discharge summary, medication list, current laboratory results, imaging reports, and other records needed for continuity or a second opinion.
Safety Net
Your dog's veterinary team should give you individualized thresholds. These general warning signs are reasons to seek veterinary guidance promptly; respiratory distress, blue/gray gums, collapse, or severe neurologic signs require emergency evaluation.
Understand the Disease
A stage is a framework—not a prognosis by itself. Kidney stage, cardiac stage, blood pressure, proteinuria, anemia, hydration, appetite, respiratory status, and the patient's response to treatment all matter.
Staging is performed in a stable, hydrated patient after CKD has been diagnosed. Creatinine and SDMA are interpreted together; IRIS also substages by proteinuria and blood pressure.
Kidney abnormality is present, but creatinine may still be within the conventional reference range.
Mild renal azotemia. Clinical signs may be absent or mild.
Moderate renal azotemia. Clinical signs and complications become increasingly common.
Severe renal azotemia with greater risk of systemic complications and uremic signs.
These A–D stages apply to myxomatous mitral valve disease (MMVD). They are different from the audible murmur grade.
Predisposed dog with no identifiable structural heart disease.
Structural disease/murmur is present, but enlargement does not meet B2 treatment criteria.
Significant cardiac enlargement meeting defined criteria; pimobendan is commonly indicated for qualifying MMVD patients.
The dog has experienced clinical congestive heart failure. A dog remains Stage C even when congestion is controlled.
End-stage disease with heart-failure signs refractory to standard therapy, requiring advanced strategies.
A veterinarian may grade an audible murmur from I/VI to VI/VI: I is very faint; II is soft but readily heard; III is moderately loud; IV is loud; V is very loud with a palpable precordial thrill; VI is very loud with a thrill and can be heard with the stethoscope slightly off the chest. A louder murmur does not by itself tell you whether a dog is in CHF. Imaging and the clinical picture determine cardiac stage.
CKD Complications
Diseased kidneys may produce inadequate erythropoietin, the hormone that signals bone marrow to make red blood cells. Iron deficiency, inflammation, shortened red-cell lifespan, bleeding, nutrition, medications, and repeated blood sampling can contribute.
CBC trends including hematocrit/PCV, hemoglobin, red-cell indices and reticulocytes; the veterinarian may also investigate iron status, bleeding, inflammation and other causes. Pale gums, weakness, poor appetite, lethargy or reduced exercise tolerance warrant attention.
IRIS now recommends treating CKD-associated anemia in dogs at HCT <30%, or persistent anemia at 30–35%, in clinical context. The number is not a stand-alone transfusion threshold.
Iron can be important when absolute or functional iron deficiency contributes to anemia, and is often considered alongside erythropoiesis-stimulating therapy. Iron should not simply be added because hematocrit is low; the cause and iron status matter.
Packed red cells or whole blood may be used for severe, clinically symptomatic anemia or acute blood loss. Transfusion can improve oxygen-carrying capacity quickly, but carries risks including reactions, volume overload, and other complications. The decision is based on the patient—not one HCT number alone.
Darbepoetin is an erythropoiesis-stimulating agent used by veterinarians for CKD-associated anemia. It acts like erythropoietin and can stimulate red-cell production over time. It requires monitoring, including blood pressure and hematologic response, and is not an emergency substitute for transfusion when immediate correction is required.
Hemodialysis does not “cure” CKD. It removes uremic toxins and manages fluid/electrolyte problems when the kidneys cannot do so adequately. It may be considered for life-threatening uremia, refractory kidney failure, dangerous overhydration, selected toxin exposures, or other severe indications at centers equipped to provide it.
Cardiorenal Safety Toolkit
Version 1.0 is designed as a set of simple, one-page tools that can be reviewed with licensed veterinarians, piloted in existing practices, and refined based on real-world use.
Document whether each chronic medication is continued, held, modified, or restarted—and why.
Carry the reasoning forward between clinicians and shifts.
Give owners the decision-relevant picture, not just raw numbers.
Make the transition home explicit and measurable.
Renal Nutrition Planning
Homemade renal diets can look simple while still being nutritionally complex. This planning tool helps owners organize calories, protein targets, water, and meal portions so they can have a more precise conversation with their veterinarian or veterinary nutritionist.
Planning aid only — not a complete renal-diet formulation.
Enter your veterinarian-approved daily targets to calculate simple per-meal amounts.
Renal Support Options
This section is designed as an educational comparison framework, not a prescription. Product formulations can change, and the appropriate choice depends on the individual patient, diet, laboratory results, concurrent medications, and veterinary assessment.
Phosphorus binders are generally used with food to reduce intestinal absorption of dietary phosphorus. Selection and amount should be individualized using the patient's diet and serial phosphorus measurements.
Ask your veterinarian: What is our phosphorus target? Should this product be given with every meal? When should phosphorus and calcium be rechecked?
Products marketed for kidney patients are not interchangeable. Some are probiotics, some are broader renal-support supplements, and their ingredients, storage requirements, intended roles, and evidence differ.
Ask your veterinarian: What problem are we trying to solve with this product? What evidence supports it? How should it be stored and given? How will we know whether it is helping?
The Happy Project can expand these pages into veterinarian-reviewed tables comparing active ingredients, intended use, administration, storage, important cautions, and strength of published evidence—without turning the website into an online prescribing service.
Why This Exists
The initiative grew out of caring for two elderly dogs with both heart and kidney disease and seeing firsthand how difficult treatment becomes when medication decisions, hydration, renal function, respiratory status, and owner communication are not considered together. Its founder is a pet owner who lost one of those dogs after a hospitalization that raised serious questions about cardiorenal medication management, clinical communication, and care transitions—and began building these tools so future owners can ask better questions earlier.
The purpose is forward-looking: help veterinary teams and owners see the same clinical picture, understand the same plan, and carry that reasoning safely from one decision point to the next.
Know Your Numbers
One value is a snapshot. A series shows direction. This browser-based tracker lets an owner record major cardiorenal variables together so renal function, anemia, blood pressure, body weight, and respiratory trends can be discussed as one picture.
Entries stay in this browser only. They are not uploaded anywhere.
| Date | Cr | BUN | Phos | SDMA | HCT | Hgb | UPC | BP | Wt | SRR | Notes |
|---|
Demonstration Case
Happy and Dopey were elderly littermates living with kidney and cardiac disease. Their records illustrate why trends can be more informative than isolated numbers. The examples below are selected owner-recorded/medical-record values and are not a controlled comparison and do not prove that one treatment caused either outcome.
Different patients—even littermates—can be in very different physiologic states. These cases are included to demonstrate longitudinal recordkeeping, not to establish causation or predict another dog's outcome.
Continuity of Care
A chronic medication list is a starting point, not a permanent treatment plan. When kidney function, weight, blood pressure, hydration, respiratory status, appetite, or clinical condition changes, ask whether the heart–kidney balance and each medication still make sense for the dog today.
Ask what changed, why it changed, what to monitor, when it will be reassessed, and whether you can have the plan in writing.
Medication changes without explanation, important trends without follow-up, or an old medication list carried forward despite major physiologic change are reasons to ask for clarification.
Never leave chronic-care follow-up undefined. Know when you are rechecking, what will be reassessed, what to monitor, and what would make you return sooner.
Printable Tools
Seven forms are built directly into this page. Fill them in on screen, then print or save them as PDFs from your browser. Fill it in on screen, then use the Print button to print or save it as a PDF from your browser.
| Marker | Prior | Today | Trend / interpretation |
|---|---|---|---|
| Creatinine | |||
| BUN | |||
| Phosphorus | |||
| Potassium | |||
| HCT / PCV | |||
| Hemoglobin |
| Medication | Continue / Hold / Change | Why |
|---|---|---|
| Medication | Dose / timing | Action | Purpose / monitoring |
|---|---|---|---|
| Date | Time | Breaths/min | Breathing effort / cough? | Notes |
|---|---|---|---|---|
| Medication | Dose | Why prescribed? | Change? |
|---|---|---|---|
| Medication / therapy | Dose | Current indication | Last change + reason | Next reassessment |
|---|---|---|---|---|
For Veterinarians
The Happy Project is owner-led. Its clinical tools are intended to be reviewed, corrected, and piloted with licensed veterinary professionals before broad adoption.
The forms do not dictate treatment. They are intended to make medication reasoning, shift handoffs, daily clinical synthesis, and discharge planning easier to document and easier for owners to understand.
Pilot concept: test the forms in a small number of cardiorenal cases, identify what adds value versus unnecessary workload, revise with veterinary input, and measure whether continuity and communication improve.
Long-Term Vision
The first phase is the cardiorenal initiative: build the toolkit, recruit veterinary reviewers, and pilot the workflows in existing practices.
If the model proves useful, the broader vision is a nonprofit veterinary-care network in Miami offering high-quality, financially accessible care, followed eventually by a dedicated facility and mobile outreach program.
What This Looks Like at Home
For many families, cardiorenal care becomes a daily routine: a gram scale on the kitchen counter, measured meals in containers, water mixed into food, medication times, respiratory-rate logs, weight checks, and a calendar full of rechecks.
The goal of The Happy Project is not to tell every owner to provide the same intensity of care. It is to make the plan understandable enough that an owner who wants to participate can do so safely, consistently, and in partnership with the veterinary team.
Future versions of the project can include owner stories showing different realistic levels of home care—from simple medication and SRR tracking to complex renal nutrition and multispecialty follow-up.
About Happy
Happy was a 15-year-old Shih Tzu—bright, demanding, sighted, still interested in food and family, and still capable of making her opinions very clear.
In July 2026, Happy entered the hospital with advanced kidney disease, dehydration, anemia, and a history of heart disease. Her renal values initially improved during hospitalization, but she ultimately deteriorated and died. Reviewing her records afterward raised serious questions for her owner about medication reconciliation, cardiorenal decision-making, communication, access to clinical information, and the transition between shifts and discharge planning.
Her littermate Dopey then became the reason to turn those questions into systems: measured nutrition, respiratory monitoring, blood-pressure tracking, deliberate medication review, scheduled follow-up, and clearer owner participation.
The Happy Project is her legacy: a practical effort to help the next family understand the whole clinical picture earlier and to make safer conversations between owners and veterinary teams easier.
Founding Network
We are looking for veterinarians, veterinary technicians, cardiology and internal-medicine professionals, nonprofit advisors, rescue groups, donors, and pet owners to review and test the model.